New Test Influences First-Line Therapy Decisions for Metastatic NSCLC Patients

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Summary: A new study from OncoHost reveals that its PROphetNSCLC test significantly impacts oncologists’ first-line treatment decisions for metastatic NSCLC.

Takeaways:

1. Enhanced Decision-Making: The PROphetNSCLC test, combined with PD-L1 expression, provides oncologists with critical additional information, influencing treatment choices for metastatic NSCLC.
2. Improved Treatment Recommendations: The study demonstrated that oncologists significantly altered their initial therapeutic recommendations after considering PROphetNSCLC test results, potentially optimizing treatment efficacy and reducing toxicity.
3. Clinical Integration: The ease of performing the PROphetNSCLC test on a single blood sample supports its integration into clinical workflows, meeting a vital need for more precise treatment strategies in NSCLC care.

OncoHost announced the publication of a study in Clinical Lung Cancer that demonstrated the impact of its PROphetNSCLC test on first-line treatment decisions for metastatic non-small cell lung cancer (NSCLC) patients.

Choosing the appropriate first-line therapy for metastatic NSCLC remains complex, with the role of new biomarkers in clinical practice still being explored. The study, “Impact of PROphet Test in Changing Physicians’ Therapeutic Decision-Making for Checkpoint Immunotherapy in Non-Small Cell Lung Cancer,” examines how the PROphetNSCLC test, a plasma proteomics machine learning-based assay, influences oncologists’ treatment choices for these patients.

“Practicing oncologists face complex therapeutic decision-making for first-line immunotherapy of metastatic NSCLC. How are they to choose among all the available regimens? Our study evaluated the addition of the PROphet predictive assay to standard PD-L1 testing,” says David R. Gandara, MD, Division of Hematology and Oncology, University of California Davis Comprehensive Cancer Center, and corresponding author of the study. “The results show that medical oncologists will embrace a test that gives them additional information on how to best manage their patients. Our study shows that we are filling an unmet need.”

NSCLC Test Study

The study found that incorporating PROphetNSCLC with PD-L1 expression significantly affected therapeutic decisions. PROphetNSCLC provides additional insights to identify patients who may benefit from various treatment options, including ICI monotherapy, combination therapy, or chemotherapy, which may help optimize treatment effectiveness and reduce toxicity.

In the study, 100 oncologists reviewed three virtual metastatic NSCLC cases with PD-L1 scores and recommended a first-line regimen. After an educational session on the PROphetNSCLC test, they re-evaluated the same cases with PROphet results, leading to notable changes in treatment recommendations.

“Our study clearly demonstrated the impact of PROphetNSCLC on treatment recommendations across a diverse group of oncologists,” says Kimberly McGregor, MD, Medical Consultant at OncoHost, and corresponding author of the study. “This finding, together with PROphetNSCLC being easily performed on a single blood sample, will facilitate adoption into clinic workflows.”

Further reading: Study Demonstrates Clinical Validity of OncoHost’s NSCLC Test